How One Study Changed What We Know About Peanut Allergy

An estimated one in 50 children in the UK has a peanut allergy. Consuming a small amount could lead to a minor reaction, such as itching and swelling, but can also lead to anaphylaxis and even death. Peanut allergy is a major cause of anaphylaxis in children. Despite its commonality – there was a 72% rise in hospital admissions for children caused by anaphylaxis in England between 2013 and 2019 – there is no cure.

Research from King’s, led by Professor Gideon Lack and Dr. Alexandra Santos from the Faculty of Life Sciences & Medicine, has made ground-breaking in-roads to our understanding of food allergy. Their work has changed the global understanding of peanut allergy and informed work on other food allergies, such as eggs, milk, shellfish, and tree nuts.

The LEAP study, led by Professor Lack, showed for the first time that early consumption of peanuts during infancy led to protection from peanut allergy. The common understanding at the time was in fact the opposite, with many parents disallowing peanuts in children’s diets.

The study found that infants who ate peanuts frequently from the first 11 months of their life were at a lower risk of developing peanut allergy at six years of age, even if they stopped eating peanuts a year prior.

The breakthrough research led to the reversal of the global public health strategy. New guidelines, including by the NHS, were issued to advise parents to introduce peanuts during weaning in infancy.

A follow-up study, EAT, expanded the list of allergens to six – egg, peanut, fish, milk, wheat, sesame – and found introducing these foods early can prevent them from developing an allergy.

Indeed, since these studies, researchers from King’s have continued to explore food allergies. A study led by Dr. Santos in 2019 found immunotherapy was protection but not a cure. They looked at the underlying behaviour of patients’ cells and found it did not change with immunotherapy.

However, there was much to look forward to in allergy research. Speaking to King’s in 2019, Dr. Santos said: “Since I started, there have been a lot of exciting new developments [in food allergy research] with new diagnostic tests and new treatments emerging and making the transition to clinical practice. The number of publications, scientific meetings, and clinicians and researchers in the field has increased significantly, which is very positive. I hope that we can stop the allergy epidemic and find curative treatments for food allergy and prevent its development in the future.”

Source: King’s College London